发明名称 |
MUTATED ANTHRAX TOXIN PROTECTIVE ANTIGEN PROTEINS THAT SPECIFICALLY TARGET CELLS CONTAINING HIGH AMOUNTS OF CELL-SURFACE METALLOPROTEINASES OR PLASMINOGEN ACTIVATOR RECEPTORS |
摘要 |
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site. |
申请公布号 |
CA2385122(C) |
申请公布日期 |
2012.12.18 |
申请号 |
CA20002385122 |
申请日期 |
2000.09.22 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE CRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
LEPPLA, STEPHEN H.;LIU, SHI-HUI;NETZEL-ARNETT, SARAH;BIRKEDAL-HANSEN, HENNING;BUGGE, THOMAS |
分类号 |
C07K14/32;A61K38/00;A61K39/07;A61K39/108;A61K47/48;A61K48/00;C07K7/06;C07K14/21;C07K14/25;C07K14/34;C07K19/00;C12N9/64;C12N9/72 |
主分类号 |
C07K14/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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