发明名称 |
High affinity VEGF-receptor antagonists |
摘要 |
A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function. |
申请公布号 |
US8334239(B2) |
申请公布日期 |
2012.12.18 |
申请号 |
US20080166042 |
申请日期 |
2008.07.01 |
申请人 |
KODADEK THOMAS;UDUGAMASOORIYA D. GOMIKA;BREKKEN ROLF;THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
KODADEK THOMAS;UDUGAMASOORIYA D. GOMIKA;BREKKEN ROLF |
分类号 |
C40B30/04 |
主分类号 |
C40B30/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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