发明名称 |
COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA |
摘要 |
Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation. |
申请公布号 |
US2012316221(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
US201213408646 |
申请日期 |
2012.02.29 |
申请人 |
KARRAS JAMES G.;GREGORY SUSAN;CROSBY JEFFREY R.;GUHA MAUSUMEE;TUNG DAVID;FREIER SUSAN M.;DOBIE KENNETH W.;ISIS PHARMACEUTICALS, INC. |
发明人 |
KARRAS JAMES G.;GREGORY SUSAN;CROSBY JEFFREY R.;GUHA MAUSUMEE;TUNG DAVID;FREIER SUSAN M.;DOBIE KENNETH W. |
分类号 |
C07H21/04;A61K31/7088;A61P11/00;A61P29/00;C12N15/113 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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