METHODS FOR PREDICTING, TREATING AND MODELLING HORMONE RESISTANCE

摘要

The present invention provides novel mutations in the gene encoding for the regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A) that are responsible for hormone resistance. Accordingly, the present invention relates to methods for predicting, treating and modelling hormone resistance. In particular, the present invention relates to a method for predicting whether a subject is at risk for having or developing a hormone resistance comprising the step consisting of detecting in a sample a mutation in PRKAR1A gene wherein the presence of said mutation is indicative of a risk of having or developing a hormone resistance.