发明名称 |
MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO |
摘要 |
The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, hydrates, and N-oxides thereof, that are useful as single pharmaceutical agents or in combination with one or more additional pharmaceutical agents, such as, an inhibitor of DPP-IV, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing secretion of an incretin; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto. |
申请公布号 |
WO2012170702(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
WO2012US41375 |
申请日期 |
2012.06.07 |
申请人 |
ARENA PHARMACEUTICALS, INC.;JONES, ROBERT, M.;BUZARD, DANIEL, J.;HAN, SANGDON;KIM, SUN, HEE;LEHMANN, JUERG |
发明人 |
JONES, ROBERT, M.;BUZARD, DANIEL, J.;HAN, SANGDON;KIM, SUN, HEE;LEHMANN, JUERG |
分类号 |
C07D401/14;A61K31/4439;A61P3/10;A61P19/00;C07D413/12;C07D413/14 |
主分类号 |
C07D401/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|