发明名称 |
COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY |
摘要 |
<p>The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.</p> |
申请公布号 |
CA2833771(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
CA20122833771 |
申请日期 |
2012.06.10 |
申请人 |
MERCK PATENT GMBH |
发明人 |
HODOUS, BRIAN L.;LIU-BUJALSKI, LESLEY;JONES, REINALDO;BANKSTON, DONALD;JOHNSON, THERESA L.;MOCHALKIN, IGOR;NGUYEN, NGAN;QIU, HUI;GOUTOPOULOS, ANDREAS;BRUGGER, NADIA |
分类号 |
C07D239/47;A61K31/4418;A61K31/505;A61K31/506;A61K31/513;A61K31/5377;A61P35/00;A61P35/02;C07D213/68;C07D213/73;C07D213/74;C07D239/48;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D413/12;C07D413/14;C07D495/04 |
主分类号 |
C07D239/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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