摘要 |
<p>Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino} acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino} acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.</p> |
申请人 |
AKEBIA THERAPEUTICS INC.;LANTHIER, CHRISTOPHER, M.;GORIN, BORIS;OUDENES, JAN;DIXON, CRAIG, EDWARD;LU, ALAN, QUIGBO;COPP, JAMES, DENSMORE;JANUSZ, JOHN, MICHAEL |
发明人 |
LANTHIER, CHRISTOPHER, M.;GORIN, BORIS;OUDENES, JAN;DIXON, CRAIG, EDWARD;LU, ALAN, QUIGBO;COPP, JAMES, DENSMORE;JANUSZ, JOHN, MICHAEL |