| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for producing a monohalogen-substituted pyridine compound for producing a 2,6-disubstituted pyridine compound highly purely and inexpensively at high yield, which is a method to be executed in an underwater reaction system, by suppressing to the utmost use of a dangerous substance having a low flash point, a combustible chemical or the like. <P>SOLUTION: In a method for producing a monohalogen-substituted heterocyclic compound (for example, 2-chloro-6-phenylanino-4-methyl-3-pyridinecarbonitrile or 6-chloro-2-phenylanino-4-methyl-3-pyridinecarbonitrile), an aniline derivative (for example, aniline) is reacted underwater with a heterocyclic compound (for example, 2,6-dichloro4-methyl-3-pyridinecarbonitrile) having two halogen atoms as a leaving group. <P>COPYRIGHT: (C)2013,JPO&INPIT |
