PARAMYXOVIRUS IMMUNOGENS AND RELATED MATERIALS AND METHODS

摘要

The present invention includes methyltransferase (MTase) -defective recombinant viruses as live vaccine candidates for human metapneumovirus (hMPV), human respiratory syncytial virus (hRSV), and human parainfluenza virus type 3 (PIV3). Here the inventors provide the technical description for generating MTase-defective paramyxoviruses useful as immunogens, as well as related materials and methods.