发明名称 |
MCAM ANTAGONISTS AND METHODS OF TREATMENT |
摘要 |
Described herein are MCAM antagonists, including MCAM antagonist antibodies capable of inhibiting the interaction between MCAM and it ligand, a laminin a4 chain, e.g., an ct4 chain of laminin 41 1. These MCAM antagonists, e.g., anti-MCAM antibodies, may be useful to treat neuroinflammatory conditions, for example, multiple sclerosis and Parkinson's disease, by inhibiting the infiltration of MCAM-expressing cells into the central nervous system (CNS), e.g., extravasation of TH 17 cells into the CNS. |
申请公布号 |
WO2012170071(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
WO2012US00274 |
申请日期 |
2012.06.06 |
申请人 |
ELAN PHARMACEUTICAS, INC;FLANAGAN, KENNETH;JOHNSTON, JENNIFER;YEDNOCK, THEODORE;BAKER, JEANNE |
发明人 |
FLANAGAN, KENNETH;JOHNSTON, JENNIFER;YEDNOCK, THEODORE;BAKER, JEANNE |
分类号 |
C07K16/30 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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