The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80 °C, thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
申请公布号
CA2838006(A1)
申请公布日期
2012.12.13
申请号
CA20122838006
申请日期
2012.06.07
申请人
GELESIS IP, LP;ONE S.R.I.
发明人
SANNINO, ALESSANDRO;DEMITRI, CHRISTIAN;ZOHAR, YISHAI;HAND, BARRY JOSEPH;RON, EYAL S.