发明名称 |
POLYMER-CONJUGATED GLYCOSYLATED NEUBLASTIN |
摘要 |
The following class of molecule is disclosed: a dimer containing a first neublastin polypeptide and a second neublastin polypeptide, wherein: (a) at least one of the polypeptides is glycosylated; (b) at least one of the polypeptides is conjugated at its N-terminus to a water-soluble synthetic polymer; and (c) neither of the polypeptides is conjugated to a water-soluble synthetic polymer at a position other than the N-terminus. Such dimers possess the biological activity of wild-type neublastin while displaying enhanced serum half-life and enhanced potency relative to wild-type neublastin. |
申请公布号 |
US2012316109(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
US201213425583 |
申请日期 |
2012.03.21 |
申请人 |
SAH DINAH WEN-YEE;PEPINSKY R. BLAKE;ROSSOMANDO ANTHONY;BIOGEN IDEC MA INC. |
发明人 |
SAH DINAH WEN-YEE;PEPINSKY R. BLAKE;ROSSOMANDO ANTHONY |
分类号 |
C07K14/475;A61K38/18;A61P25/00;A61P25/02;C12N;C12N15/00 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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