发明名称 |
PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES |
摘要 |
<p>Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino} acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino} acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.</p> |
申请公布号 |
CA2838194(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
CA20122838194 |
申请日期 |
2012.06.05 |
申请人 |
AKEBIA THERAPEUTICS INC. |
发明人 |
LANTHIER, CHRISTOPHER M.;GORIN, BORIS IVANOVICH;OUDENES, JAN;DIXON, CRAIG EDWARD;LU, ALAN QUIGHO;COPP, JAMES DENSMORE;JANUSZ, JOHN MICHAEL |
分类号 |
C07D213/62 |
主分类号 |
C07D213/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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