发明名称 |
BINDING COMPOUNDS TO HUMAN .BETA.1-ADRENORECEPTOR (.BETA.1-AR) AND THEIR USE IN THE MEASUREMENT OF AUTO-ANTI-.BETA.1-AR ANTIBODIES |
摘要 |
The present disclosure relates to binding compounds/antibodies that bind to the second extracellular loop of the human ß1-adrenoreceptor (ß1-AR-ECII) that are produced by/obtainable from a host cell/hybridoma with a deposit number selected from the group consisting of DSM ACC3121, DSM ACC3174, DSM ACC3175, DSM ACC3176 and DSM ACC3177. The binding compounds/antibodies are particularly useful in determination of auto-anti-ß1-AR antibodies in an in vitro cell based assay system in order to characterize and to identify auto-antibodies directed against the ß1-AR-ECII in a biological sample. Further aspects of the disclosure are nucleic acid molecules encoding said binding compounds/antibodies, vectors, host cells, methods for producing the binding compounds/antibodies of the disclosure as well as a kit comprising the binding compounds/antibodies of the present disclosure. |
申请公布号 |
CA2835231(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
CA20122835231 |
申请日期 |
2012.06.06 |
申请人 |
CORIMMUN GMBH |
发明人 |
HOLTHOFF, HANS-PETER;UNGERER, MARTIN;ZEIBIG, STEFAN;LOHSE, MARTIN J.;JAHNS, ROLAND;JAHNS, VALERIE |
分类号 |
C07K16/28;G01N33/564 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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