发明名称 |
WEAKLY BASIC 2- NITROIMIDAZOLES FOR THE NON-INVASIVE DETECTION OF TISSUE HYPOXIA |
摘要 |
The present invention incorporates weakly basic substituents (pKa about 8 or greater) such as pyrrolidine, piperidine, piperazine and azapane moieties in halogenated 2-nitromidazoles for the non-invasive detection of cellular hypoxia in normal and malignant tissues. The compounds of the invention can be used in 18F positron emission tomography, 19F magnetic resonance spectroscopy, and 19F magnetic resonance imaging. |
申请公布号 |
EP2086592(A4) |
申请公布日期 |
2012.12.12 |
申请号 |
EP20070871100 |
申请日期 |
2007.10.01 |
申请人 |
NATURAL PHARMACIA INTERNATIONAL, INC. |
发明人 |
RALEIGH, JAMES A.;LEE, DAVID, Y-W;JI, XIAOSHEN |
分类号 |
A61K51/04;A61K49/06;A61K101/02;G01N33/531 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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