| 摘要 |
PURPOSE: A fluorine-18 labeled triazanonane derivative for ischemic tissue imaging is provided to stably form a complex and to enable PET(Positron Emission Tomography) for determining stroma, cerebrovascular diseases, cancer, nervous diseases, and coronary artery diseases. CONSTITUTION: A triazanonane derivative is denoted by chemical formula 1. The derivative of chemical formula 1 forms a complex together with metals and fluoride. The metal includes aluminum, gallium, indium, thallium, yttrium, or ruthenium. A radiopharmaceutical product contains the derivative of chemical formula 1 and the complex of metals and fluoride as an active ingredient. A method for preparing the derivative of chemical formula 1 comprises: a step of dissolving NODA compounds of chemical formula 2 and a base in an organic solvent; a step of adding nitroimidazole or nitrotriazole compounds to prepare a compound of chemical formula 3; and a step of dissolving the compound of chemical formula 3 in the organic solvent and performing deprotection. [Reference numerals] (AA) Step 1; (BB) Step 2
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