发明名称 |
DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) FOR USE IN TREATMENT OF DISEASES ASSOCIATED WITH A PTEN DEFICIENCY |
摘要 |
<p>A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.</p> |
申请公布号 |
EP2531033(A1) |
申请公布日期 |
2012.12.12 |
申请号 |
EP20110740322 |
申请日期 |
2011.02.03 |
申请人 |
BIOMARIN PHARMACEUTICAL INC. |
发明人 |
CHU, DANIEL;WANG, BING;FENG, YING;SHEN, YUQIAO;POST, LEONARD, EDWIN |
分类号 |
A61K31/5025;A61K31/5377 |
主分类号 |
A61K31/5025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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