发明名称 |
TUSSUE-REGENERATION PROMOTER USING RECRUITMENT OF BONE MARROW MESENCHYMAL STEM CELLS AND/OR PLURIPOTENT STEM CELLS IN BLOOD |
摘要 |
It was revealed that the intravenous administration of HMGB-1 and S100A8 promoted the healing of skin ulcer by recruiting bone marrow-derived cells to the site of skin ulcer. Furthermore, when HMGB-1 was intravenously administered to cerebral infarction model mice after creation of cerebral infarction, bone marrow-derived cells expressing nerve cell markers were detected in their brain. A marked cerebral infarct-reducing effect was observed in mice intravenously administered with HMGB-1 as compared to the control. The post-cerebral infarction survival rate was increased in the intravenous HMGB-1 administration group. The involvement of bone marrow pluripotent stem cells in the process of bone fracture healing was assessed using mice, and the result demonstrated that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue. |
申请公布号 |
KR20120135190(A) |
申请公布日期 |
2012.12.12 |
申请号 |
KR20127013657 |
申请日期 |
2010.10.28 |
申请人 |
OSAKA UNIVERSITY;GENOMIX CO., LTD. |
发明人 |
TAMAI KATSUTO;KANEDA YASUFUMI;YAMAZAKI TAKEHIKO;CHINO TAKENAO;SAGA KOTARO;ENDO MAYUMI |
分类号 |
A61K35/28;A61K38/17;A61K48/00;C07K14/47 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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