发明名称 |
Cycloalkane-containing sphingosine 1-phosphate agonists |
摘要 |
The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type, which alter lymphocyte trafficking. The compounds of the invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates. |
申请公布号 |
US8329676(B2) |
申请公布日期 |
2012.12.11 |
申请号 |
US20100834884 |
申请日期 |
2010.07.12 |
申请人 |
LYNCH KEVIN R.;MACDONALD TIMOTHY L.;UNIVERSITY OF VIRGINIA PATENT FOUNDATION |
发明人 |
LYNCH KEVIN R.;MACDONALD TIMOTHY L. |
分类号 |
A61K31/661;A61K31/133;C07C215/44;C07F9/09 |
主分类号 |
A61K31/661 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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