Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase

摘要

PURPOSE: A peptide which suppresses HMG-CoA reductase is provided to competitively suppress the enzyme and to obtain a cholesterol synthesis inhibitor which treats cardiovascular diseases. CONSTITUTION: A peptide contains one or more sequences selected from the group consisting of sequence numbers 1-5. The peptide competitively suppresses HMG-CoA redutase. A cholesterol synthesis inhibitor contains the peptide containing a sequence selected from the group consisting of sequence numbers 1-5. The cholesterol synthesis inhibitor is used for preventing and treating cardiovascular diseases.