PHENYLCYCLOHEXYL DERIVATIVES AS DGAT1 INHIBITORS

摘要

The present invention provides organic compounds of the following structure; A-L1-B-C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 acitvity in animals, particularly in humans. In a specific embodiment, the invention relates to a compound as represented by figure "B": (see formula "B"), or a pharmaceutically acceptable salt thereof wherein: - A is a substituted or unsubstituted alkyl, cycloalkyl, aryl, or heterocyclyl group; - L1 is selected from the group consisting of: * an amine group -NH-* a substituted amine group of the formula -N(CH3)-, -CH2-NH- or -CH2-CH2-NH-, etc - B is a substituted or unsubstituted, monocyclic, 5- or 6-membered divalent heteroaryl group; - C is a substituted or unsubstituted divalent phenyl group; - L2 is selected from the group consisting of: * a single bond, etc - E is selected from the group consisting of: * a sulphonic acid group and derivatives thereof, etc with the provisos that - E is not a carboxamide group if L2 comprises an amide group, and - L2 is not a divalent N-methyl piperidinyl group if the moiety E is a pyridinyl-1,2,4-triazolyl group.