发明名称 Isotopically labeled chemically stable reagents and process for the synthesis thereof
摘要 A radioisotope labeled reagent includes a compound having the general formula (I), L-(aCbH2)naC5bH3  (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1—S—, 12C1H3(12C1H2)n—S—R1C(O)O—, NC—, (R1)3P—, XMg— and Li—, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1 is H, aryl, a substituent containing aryl, C1-C20 alkyl, a substituent containing C1-C20 alkyl, C2-C20 alkenyl, a substituent containing C2-C20 alkenyl, C2-C20 alkynyl, and a substitute containing C2-C20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1 in R1—S is not aryl.
申请公布号 US8329934(B2) 申请公布日期 2012.12.11
申请号 US201113231041 申请日期 2011.09.13
申请人 POUNDS JERRY SCOT;PERKINELMER HEALTH SCIENCES, INC. 发明人 POUNDS JERRY SCOT
分类号 C07C309/29;C07B59/00;C07C;C07C67/10;C07C303/26;C07C309/63;C07C309/73;C07D207/04;C07D207/09;C07D211/66;C07D453/02 主分类号 C07C309/29
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