发明名称 |
Methods for producing ECM-based biomaterials |
摘要 |
A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume. |
申请公布号 |
US8329219(B2) |
申请公布日期 |
2012.12.11 |
申请号 |
US20090644607 |
申请日期 |
2009.12.22 |
申请人 |
FARRELL LAURA-LEE;JOHNSON CHAD E.;COOK BIOTECH INCORPORATED;COOK MEDICAL TECHNOLOGIES LLC |
发明人 |
FARRELL LAURA-LEE;JOHNSON CHAD E. |
分类号 |
A61K9/14;A61P17/02;B29C41/04 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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