发明名称 |
Tim-3 ligands and methods thereof |
摘要 |
The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.
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申请公布号 |
US8329660(B2) |
申请公布日期 |
2012.12.11 |
申请号 |
US20040958169 |
申请日期 |
2004.10.04 |
申请人 |
KUCHROO VIJAY K.;STROM TERRY;CHA EUGENE K.;CHAKRAVARTI SUMONE;SABATOS CATHERINE;ZHU CHEN;ZHENG XIN XIAO;SANCHEZ-FUEYO ALBERTO;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
KUCHROO VIJAY K.;STROM TERRY;CHA EUGENE K.;CHAKRAVARTI SUMONE;SABATOS CATHERINE;ZHU CHEN;ZHENG XIN XIAO;SANCHEZ-FUEYO ALBERTO |
分类号 |
A61K39/395;C07H21/04;C07K14/47;C07K14/705;C07K16/18;C07K16/28;C12N5/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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