发明名称 |
MEMS interstitial prothrombin time test |
摘要 |
A method of determining a prothrombin time is disclosed. A mediator is applied to a stratum corneum. The stratum corneum is penetrated to allow the mediator to enter a region containing interstitial fluid and interact with at least one capillary, causing blood and/or blood components to leak from the at least one capillary into the region containing interstitial fluid. A characteristic affected by the blood and/or blood components is measured in the region containing interstitial fluid which correlates to the prothrombin time. A system for measuring prothrombin time is also disclosed. The system has a mediator, one or more microneedles, and a processor directly or indirectly coupled to the one or more microneedles and configured to determine a coagulation change in blood or blood components in a region around the one or more microneedles after the one or more microneedles penetrate a stratum corneum. |
申请公布号 |
US8328720(B2) |
申请公布日期 |
2012.12.11 |
申请号 |
US20080189509 |
申请日期 |
2008.08.11 |
申请人 |
MIR JOSE;KOWARZ MAREK W.;SARBADHIKARI KAMAL K.;ASHE PHILIP RYAN;INFOTONICS TECHNOLOGY CENTER, INC. |
发明人 |
MIR JOSE;KOWARZ MAREK W.;SARBADHIKARI KAMAL K.;ASHE PHILIP RYAN |
分类号 |
A61B5/1459 |
主分类号 |
A61B5/1459 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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