发明名称 |
Antisense antiviral compound and method for treating picornavirus infection |
摘要 |
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5′ untranslated region identified by SEQ ID NO:4. |
申请公布号 |
US8329668(B2) |
申请公布日期 |
2012.12.11 |
申请号 |
US20060518058 |
申请日期 |
2006.09.08 |
申请人 |
STEIN DAVID A.;RIJNBRAND CORNELIS A.;IVERSEN PATRICK L.;WELLER DWIGHT D.;AVI BIOPHARMA, INC. |
发明人 |
STEIN DAVID A.;RIJNBRAND CORNELIS A.;IVERSEN PATRICK L.;WELLER DWIGHT D. |
分类号 |
C12N15/11;C07H21/04;C12Q1/68 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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