2-(PIPERIDIN-4-YL)-4-PHENOXY- OR PHENYLAMINOPYRIMIDINE DERIVATIVES AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

摘要

FIELD: chemistry.SUBSTANCE: present invention refers to compounds of formula I or their pharmaceutically acceptable salts showing activity with respect to HIV reverse transcriptase, as well as to a based pharmaceutical composition(I). In formula I Rmeans phenyl(C-C)alkyl, heteroaryl(C-C)alkyl, phenyl or heteroaryl optionally substituted by one-three substitutes independently specified in groups (a)-(r), Rmeans -CN, -CH=CHCN or halogen; Rmeans hydrogen, halogen, amino group, halogen(C-C)alkyl, -CN or methyl; Rmeans hydrogen, Br or amino group; Rand Rindependently mean hydrogen, C-Calkyl, C-Calkoxy group or halogen; Rand Reither independently mean hydrogen, or together mean ethylene; X means NH or O. The groups (a)-(r) are such as presented in the patent claim.EFFECT: preparing pharmaceutically acceptable salts possessing activity with respect to HIV reverse transcriptase.17 cl, 42 ex, 6 dwg, 5 tbl