| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to methods of producing 3-endo(8-azabicyclo[3.2.1]oct-3-yl)benzamide of formula 1. The methods are realised via hydrogenation of an intermediate product, amine-protected 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)benzamide of formula 3, in the presence of hydrochloric or trifluoroacetic acid, where the amine-protective group is a removable by catalytic hydrogenation. The invention also relates to intermediate compounds2,3 and5, a method of producing a compound of formula 3 and a method of increasing stereospecifity for endo-orientation of a 3-endo(8-azabicyclo[3.2.1]oct-3-yl)benzamide sample.EFFECT: improved methods of producing 3-endo(8-azabicyclo[3,2,1]oct-3-yl)benzamide.14 cl, 1 dwg, 4 ex |
