METHOD FOR DETECTION OF GENETIC PREDISPOSITION TO DEVELOPING MYOCARIAL INFARCTION IN INDIVIDUALS WITH NO CLINICAL IMPLICATIONS OF ISCHEMIC HEART DISEASE

摘要

FIELD: medicine.SUBSTANCE: invention refers to a method for detection of genetic predisposition in an individual with no clinical implications of ischemic heart disease (IHD) to developing myocardial infarction (MI). The invention may be used in cardiology for detection of genetic predisposition to developing myocardial infarction (MI). A combination of two pathogenetically MI-related polymorphisms representing single nucleotide substitutes C1019T in connexin-37 (Cx37) gene and G894T in endothelial NO-CHHTa3bi.(eNOS) gene are examined. A high degree of risk of developing MI in an individual being examined is stated by a combination of homozygous genotype TT in C1019T polymorphism of Cx37 gene and homozygous genotype GG in G894T polymorphism of eNOS gene.EFFECT: invention enables specifying a group of high risk of developing MI among almost healthy persons for the purpose of taking primary prevention actions.2 dwg, 7 tbl, 4 ex