AMINONICOTINIC ACID AND ISONICOTINIC ACID DERIVATIVES AS DHODG (DIHYDROOROTATE DEHYDROGENASE) INHIBITORS

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to new compounds of formula (I) and its pharmaceutically acceptable salts possessing dihydroorotate dehydrogenase inhibitory ability, to a based pharmaceutical composition, to application thereof in preparing a drug compound and to a combined preparation containing the presented compounds and the other active compound(I) in effective amounts wherein both groups Gmean CR, Gmean a nitrogen atom or group CR, of the groups Gand Gmean a nitrogen atom and the other one means group CH, M means a hydrogen atom or a pharmaceutically acceptable cation, while R, R, R, R, Rand Rhave the values specified in the patent claim.EFFECT: preparing pharmaceutically acceptable salts possessing dihydroorotate dehydrogenase inhibitory ability.25 cl, 115 ex, 2 tbl