| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel imidazopyridine compounds of formula (I) and pharmaceutically acceptable salts thereof, which inhibit kinase activity, selected from IGF-1R, IR, EGFR and Erb2 and have cell proliferation inhibitor properties. In formula(I) halogeno denotes a halogen; Xis H or halogen, Ris H, halogen or halogen-C-Calkyl; Ris H or O-C-Calkyl; each Ris identical or different and is independently selected from H, halogen, C-Calkyl, halogen-C-Calkyl and O-C-Calkyl; one of Rand Ris selected from H, halogen, C-Calkyl and O-C-Calkyl; and the other is a group selected from:(i),(ii) and(iii) where:(1) each Ris H; a equals 0, 1, 2 or 3; Ris selected from NH, N(H)C-Calkyl, N(C-Calkyl)and a group of formula (iv):(iv), where: ring D is a 5-6-member saturated N-heterocycle, possibly containing 1 or 2 additional heteroatoms selected from N and O. Other values of radicals are given in the claim.EFFECT: compounds can be used in treating different types of cancer.4 tbl, 250 ex |
