摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention declares a compound of structural formula(I) or its pharmaceutically acceptable salt, solvate or hydrate wherein: X is phenol opiate wherein a hydrogen atom of a hydroxyl phenol group of substituted by a covalent bond with -C(O)-Y-(C(R)(R))-N-C(R)(R);Y is -NR-, Ris (C)alkyl; n is equal to 2 or 3, each of Rand Ris independently hydrogen, alkyl or substituted alkyl; Ris hydrogen or methyl; Ris a residue of L-amino acid or a residue of their N-acyl derivatives, as well as Hydromorphone 3-(N-methyl-N-(2-N'-acetylarginine amino)ethyl carbamate, or their pharmaceutically acceptable salt. What is also specified is a method for preparing the compound of formula (I) or its pharmaceutically acceptable salt.EFFECT: what is declared is a pharmaceutical composition controlling phenol opiate release and a method of pain management in a patient in need thereof involving the introduction of an effective amount of the composition.19 cl, 20 ex, 12 tbl |