Novel Hydroxamic Acids Having Histone Deacetylase Inhibiting Activity and Pharmaceutical Composition for Treating Cancer Comprising the Same As Active Ingredient

摘要

PURPOSE: A novel hydroxamic acid and a pharmaceutical composition containing the same for anti-cancer are provided to suppress histone deacetylase(HDAC) and to be used as a strong anti-cancer agent. CONSTITUTION: A novel hydroxamic acid compound is denoted by chemical formula 1, 2, 3, 4, or 5. In chemical formulas 1-4, R is alkyl of -H or C1-C5, alkoxy of C1-C5, -SO_2CH_3, or -NO_2. In chemical formula 5, R is -H, halo, alkoxy of C1-C5, -NO_2, or -CN. A pharmaceutical composition for anti-cancer contains a compound of chemical formula 1, 2, 3, 4, or 5 as an active ingredient.