CYANOQUINOLINE COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT-CFTR PROCESSING AND INCREASING ION TRANSPORT AND USES THEREOF
摘要
<p>The present disclosure provides pharmaceutical compositions, pharmaceutical preparations and methods for increasing activity of a mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR). The pharmaceutical compositions, pharmaceutical preparations and methods are useful for the study and treatment of disorders associated with mutant-CFTR, such as cystic fibrosis. The pharmaceutical compositions and pharmaceutical preparations may include one or more cyanoquinoline-containing compounds of the embodiments, or an analog or derivative thereof.</p>
申请公布号
WO2012166654(A1)
申请公布日期
2012.12.06
申请号
WO2012US39706
申请日期
2012.05.25
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;VERKMAN, ALAN S.;PHUAN, PUAY-WAH;KURTH, MARK J.;KNAPP, JOHN
发明人
VERKMAN, ALAN S.;PHUAN, PUAY-WAH;KURTH, MARK J.;KNAPP, JOHN