发明名称 Benzazepine derivatives useful as vasopressin antagonists
摘要 <p>The present invention provides a benzazepine compound that can maintain for a long period of time the blood level of tolvaptan enabling to provide the desired pharmaceutical effects. The benzazepine compound of the present invention is represented by general formula (1) wherein Rrepresents a -CO-(CH)-COR group (wherein n is an integer of 1 to 4, and R is (2-1) a hydroxy group; (2-2) a lower alkoxy group optionally substituted with a hydroxy group, a lower alkanoyl group, a lower alkanoyloxy group, a lower alkoxycarbonyloxy group, a cycloalkyloxycarbonyloxy group, or 5-methyl-2-oxo-1,3-dioxol-4-yl; or (2-3) an amino group optionally substituted with a hydroxy-lower alkyl group), or the like.</p>
申请公布号 AU2008269918(B2) 申请公布日期 2012.12.06
申请号 AU20080269918 申请日期 2008.06.26
申请人 OTSUKA PHARMACEUTICAL CO., LTD. 发明人 MATSUDA, TAKAKUNI;KATO, YUSUKE;TOMOYASU, TAKAHIRO;MIYAMURA, SHIN;KONDO, KAZUMI;YAMADA, KEIGO;MENJO, YASUHIRO;TOMOHIRA, YUSO
分类号 C07D223/16;A61K31/55;A61P7/00;A61P9/00;C07D405/12 主分类号 C07D223/16
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