<p>Leptin muteins, in particular leptin antagonists, with increased binding affinity to leptin receptor are provided. These compounds as well as pharmaceutical composition comprising them are useful for the treatment of any disorder in which a non-desirable or deleterious activity of endogenous leptin or an altered innate immune response is implicated.</p>
申请公布号
AU2011243965(A1)
申请公布日期
2012.12.06
申请号
AU20110243965
申请日期
2011.04.17
申请人
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM LTD;THE MEDICAL RESEARCH, INFRASTRUCTURE