发明名称 |
COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
摘要 |
The present invention concerns compounds, some of which are novel, and their pharmaceutical applications. The compounds of the invention inhibit the enzyme lactate dehydrogenase (LDH) involved both in the metabolic process of hypoxic tumour cells, and in the process used by parasitic protozoa that cause malaria to obtain most of the energy they need. |
申请公布号 |
US2012309794(A1) |
申请公布日期 |
2012.12.06 |
申请号 |
US201013508473 |
申请日期 |
2010.11.05 |
申请人 |
MINUTOLO FILIPPO;MACCHIA MARCO;GRANCHI CARLOTTA;ROY SARABINDU;GIANNACCINI GINO;LUCACCHINI ANTONIO;UNIVERSITA DI PISA |
发明人 |
MINUTOLO FILIPPO;MACCHIA MARCO;GRANCHI CARLOTTA;ROY SARABINDU;GIANNACCINI GINO;LUCACCHINI ANTONIO |
分类号 |
A61K31/404;A61K31/41;A61K31/4184;A61K31/4192;A61K31/4245;A61K31/426;A61K31/4439;A61P35/00;C07D209/42;C07D235/26;C07D277/46;C07D401/14;C07D403/10;C07D413/10 |
主分类号 |
A61K31/404 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|