MUTANT REPLICON DERIVED FROM GENOME OF HEPATITIS C VIRUS J6CF STRAIN

摘要

The present invention provides a nucleic acid containing a hepatitis C virus J6CF strain genome 5'-untranslated region, a virus protein coding region containing an NS3 protein coding sequence, an NS4A protein coding sequence, an NS4B protein coding sequence, an NS5A protein coding sequence and an NS5B protein coding sequence, and a 3'-untranslated region, in order from the 5' side to the 3' side. Therein, the NS4A protein coding sequence has a mutation substituting glutamic acid for the 1680th alanine, when the amino acid sequence of a J6CF strain precursor protein is used as a reference.