PYRIDOTHIAZEPINE DERIVATIVE, PREPARATION METHOD AND USES THEREFOR

摘要

The present invention belongs to the field of medicine and relates to a pyridothiazepine derivative and a preparation method and uses therefor. Pyridothiazepine derivatives have a wide range of antineoplastic activity, said compounds exhibiting excellent inhibitive effect on various human carcinoma cell lines in in vitro cell tests; said cell lines include human leukemia cell line OP-1, human colon carcinoma cell line HT29, human lung carcinoma cell line H460, paclitaxel-resistant human lung carcinoma cell line H460TaxR, and doxorubicin-resistant human breast carcinoma cell line MCF-7/Adr. The compounds can independently or together with active ingredients of other anticancer drugs be mixed with pharmaceutical excipients to form a pharmaceutical formulation that can be used to treat various carcinomas.