| 发明名称 |
DIARYLHYDANTOIN COMPOUND |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide diarylhydantoin compounds including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer. <P>SOLUTION: The invention encompasses a method for treating a hyperproliferative disorder comprising a step of administering a composition to a subject in need of such treatment, thereby treating the hyperproliferative disorder. The invention provides a series of compounds having strong antagonistic activities with minimal agonistic activities against AR. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2012236843(A) |
申请公布日期 |
2012.12.06 |
| 申请号 |
JP20120168904 |
申请日期 |
2012.07.30 |
| 申请人 |
REGENTS OF THE UNIV OF CALIFORNIA |
发明人 |
SAWYERS CHARLES L;JUNG MICHAEL E;CHEN CHARLIE D;OUK SAMEDY;WELSBIE DEREK;TRAN CHRIS;WONGVIPAT JOHN;YOO DONGWON |
| 分类号 |
A61K31/4166;A61K9/08;A61K9/10;A61K9/14;A61K9/20;A61K9/48;A61K9/52;A61P5/26;A61P5/28;A61P35/00;A61P43/00;C07D233/74;C07D233/84;C07D233/86;C07D233/88;C07D235/02;C07D401/04;C07D403/04;C07D471/10 |
主分类号 |
A61K31/4166 |
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