| 发明名称 |
USE OF DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) IN THE TREATMENT OF MYELODYSPLASTIC SYNDROME (MDS) AND ACUTE MYELOID LEUKAEMIA (AML) |
| 摘要 |
<p>Disclosed herein are compounds of Formula (I) where R1, R2, R3, R4, R5, A, B, Y, and Z are as defined herein for use in the treatment of MDS or AML. Also disclosed are the methods of identifying a patient with MDS or AML who is sensitive to treatment with a PARP inhibitor, in particular a compound of Formula (I).</p> |
| 申请公布号 |
WO2012166151(A1) |
申请公布日期 |
2012.12.06 |
| 申请号 |
WO2011US39045 |
申请日期 |
2011.06.03 |
| 申请人 |
BIOMARIN PHARMACEUTICAL INC.;POST, LEONARD;MUFTI, GHULAM, J.;GAYMES, TERRY, J. |
发明人 |
POST, LEONARD;MUFTI, GHULAM, J.;GAYMES, TERRY, J. |
| 分类号 |
A61K31/5025;A61P35/02;C12Q1/68 |
主分类号 |
A61K31/5025 |
| 代理机构 |
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代理人 |
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| 地址 |
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