发明名称 |
Neutralising prolactin receptor antibody Mat3 and its therapeutical use |
摘要 |
The neutralizing prolactin receptor antibody Mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody blocks prolactin receptor-mediated signalling. |
申请公布号 |
EP2530089(A1) |
申请公布日期 |
2012.12.05 |
申请号 |
EP20110168644 |
申请日期 |
2011.06.03 |
申请人 |
BAYER PHARMA AKTIENGESELLSCHAFT |
发明人 |
FREIBERG, CHRISTOPH;OTTO, CHRISTIANE;LINDEN, LARS;HARRENGA, ALEX;TRAUTWEIN, MARK;GREVEN, SIMONE;WILMEN, ANDREAS |
分类号 |
C07K16/28;A61K39/395;A61P5/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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