发明名称 |
Methods of intracellular conversion of single-chain proteins into their di-chain form |
摘要 |
The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form. |
申请公布号 |
EP2528940(A1) |
申请公布日期 |
2012.12.05 |
申请号 |
EP20110702755 |
申请日期 |
2011.01.24 |
申请人 |
ALLERGAN, INC. |
发明人 |
GHANSHANI, SANJIV;LE, LINH Q.;LIU, YI;STEWARD, LANCE E. |
分类号 |
C07K14/33;C12N9/50;C12N15/62;C12N15/70;C12N15/866;C12P21/02;C12P21/06 |
主分类号 |
C07K14/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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