发明名称 |
METHODS FOR ENHANCING ANTI-TUMOR ANTIBODY THERAPY. |
摘要 |
Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule. |
申请公布号 |
MX2012006420(A) |
申请公布日期 |
2012.12.05 |
申请号 |
MX20120006420 |
申请日期 |
2010.12.07 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
HOLBROOK KOHRT;ROCH HOUOT;RONALD LEVY;MATTHEW J. GOLDSTEIN;JAMES TORCHIA;ARASH ASH ALIZADEH |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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