发明名称 |
TISSUE ENGINEERING TENDON AND CONSTRUCTION METHODS IN VITRO THEREOF |
摘要 |
The invention discloses a tissue engineering graft, comprising:(a) pharmaceutically-acceptable biodegradable material; and (b) seed cells, which can be inoculated on the described biodegradable material and are selected from:(i) fibroblasts; (ii) adipose derived cells, or (iii) mixture of dermal fibroblasts and ASCs according to the ratio of 1:10000-10000:1. The graft can be prepared by mixing of seed cell and pharmaceutically-acceptable biodegradable material, obtaining a construct of seed cells and pharmaceutically-acceptable biodegradable material, then culturing the construct in a bioreactor in vitro. The graft can be used for repairing the defect of tendon tissues. |
申请公布号 |
EP2172231(A4) |
申请公布日期 |
2012.12.05 |
申请号 |
EP20080715302 |
申请日期 |
2008.03.24 |
申请人 |
SHANGHAI TISSUE ENGINEERING LIFE SCIENCE CO. LTD.;SHANGHAI 9TH PEOPLE'S HOSPITAL, SHANGHAI JIAOTONGUNIVERSITY SCHOOL OF MEDICINE |
发明人 |
CAO, YILIN;LIU, WEI;XU, FENG;DENG, DAN;LI, HONG |
分类号 |
A61L27/38;A61F2/08;A61K35/12;A61L27/58;C12N5/077 |
主分类号 |
A61L27/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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