| 发明名称 |
CONNECTIVE TISSUE GROWTH FACTOR |
| 摘要 |
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides CTGF, and including 5'and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
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| 申请公布号 |
CA2222509(C) |
申请公布日期 |
2012.12.04 |
| 申请号 |
CA19962222509 |
申请日期 |
1996.05.31 |
| 申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
GROTENDORST, GARY R.;BRADHAM, DOUGLASS M. |
| 分类号 |
C12N15/09;C12N15/18;A61K31/70;A61K38/00;A61K38/16;A61K38/18;A61K38/27;A61K39/395;A61K45/00;A61K48/00;A61P9/10;A61P11/00;A61P13/12;A61P17/02;A61P27/06;A61P35/00;A61P43/00;C07K14/475;C07K14/495;C12N5/077;C12Q1/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
C12N15/09 |
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