| 发明名称 |
Method of screening for compounds that inhibit the enzymatic activity of GWT1 gene product |
| 摘要 |
The present invention enables screening for compounds that inhibit the transport of GPI-anchored proteins to fungal cell walls, using a simple assay for transacylation to GlcN-PI using membrane fraction expressing GWT1 protein. New antifungal agents can be created that inhibit the synthesis of fungal cell walls and also inhibit adhesion to host cells by inhibiting the transport of GPI-anchored proteins to fungal cell walls. |
| 申请公布号 |
US8323917(B2) |
申请公布日期 |
2012.12.04 |
| 申请号 |
US20030536935 |
申请日期 |
2003.11.21 |
| 申请人 |
TSUKAHARA KAPPEI;TSUCHIYA MAMIKO;JIGAMI YOSHIFUMI;NAKAYAMA KENICHI;UMEMURA MARIKO;OKAMOTO MICHIYO;NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY;EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
TSUKAHARA KAPPEI;TSUCHIYA MAMIKO;JIGAMI YOSHIFUMI;NAKAYAMA KENICHI;UMEMURA MARIKO;OKAMOTO MICHIYO |
| 分类号 |
G01N33/53;C07H21/04;C07K1/00;C07K14/00;C07K17/00;C12N15/55;C12Q1/18;C12Q1/48;C12Q1/68;G01N33/569 |
主分类号 |
G01N33/53 |
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