发明名称 |
Administration of exogenous miRNA or siRNA |
摘要 |
Certain genes controlled by endogenous miRNA are actually upregulated upon the transfection of exogenous mi/siRNA. Based on this, methods of determining whether administration of mi/siRNA will have a deleterious effect by upregulating certain genes are provided. Comparison of sequences of exogenous mi/siRNA allows selection of exogenous miRNA to be administered to cell to enhance or limit this affect, and therefore to control unwanted disregulation, or to upregulate an endogenous miRNA-regulated gene of interest. |
申请公布号 |
US8323893(B2) |
申请公布日期 |
2012.12.04 |
申请号 |
US20100907966 |
申请日期 |
2010.10.19 |
申请人 |
LESLIE CHRISTINA S.;MARKS DEBORA S.;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
LESLIE CHRISTINA S.;MARKS DEBORA S. |
分类号 |
C12Q1/68;C07H21/04;C12N5/00;C12N5/02;C12N15/11 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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