发明名称 |
OSMOTIC DEVICE CONTAINING A VENLAFAXINE SALT AND A SALT HAVING AN ION IN COMMON |
摘要 |
The osmotic devices of the present invention include a single core comprising a salt of a drug and an osmotic salt, wherein the drug salt and the osmotic salt have a common ion. The release rate of the active drug is reduced, and the release profile of the active drug is modified, from a first order release profile to a zero order, pseudo-zero order, or sigmoidal release profile, by increasing the amount of the sodium chloride in the core of the device. In one embodiment the sodium chloride is used to modify a controlled release profile to a delayed and controlled release profile.
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申请公布号 |
CA2551751(C) |
申请公布日期 |
2012.12.04 |
申请号 |
CA20052551751 |
申请日期 |
2005.01.03 |
申请人 |
OSMOTICA COSTA RICA, SOCIEDAD ANONIMA |
发明人 |
FELEDER, ETHEL C.;MEYER, GLENN A.;RICCI, MARCELO A.;BEFUMO, MARCELO F.;FAOUR, JOAQUINA;PASTINI, ANA C. |
分类号 |
A61K31/137;A61K9/00;A61K9/24;A61K31/13;A61K31/277 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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