INTRANASAL CARBETOCIN FORMULATIONS AND METHODS FOR THE TREATMENT OF AUTISM

摘要

Provided is a pharmaceutical formulation for intranasal delivery of carbetocin, comprising carbetocin, a solubilizer, a chelator, a tonicifier, and two or more buffers wherein the solubilizer is methyl-beta-cyclodextrin and the chelator is EDTA. The tonicifier can be sodium chloride, and the buffer arginine and acetate. The formulation can further comprise a preservative which is benzalkonium chloride, chlorobutanol, methyl paraben, or propyl paraben and a preservative which is chlorobutanol.